自主振荡时间与中澳门永利官网心体生物发生理论2020-06-15 16:03

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本期文章:《细胞》:Online/在线发表

英国牛津大学Jordan W. Raff、Mustafa G. Aydogan和剑桥大学Michael A. Boemo研究组合作,提出了一个自治振荡时间并执行中心体生物发生的理论。2020年6月11日,《细胞》在线发表了这一成果。

研究人员发现中心粒发生的起始阶段,Polo样激酶4(Plk4)的振荡会引发并对中心粒生物发生计时以确保中心粒在正确的时间以适当的大小生长。Plk4振荡通常伴随细胞周期振荡,但可以自发运行。这潜在地解释了为什么中心粒可以独立于细胞周期进程进行复制。

数学模型表明,Plk4振荡可以由一个延时的负反馈回路产生,在该回路中,澳门永利网址,Plk4通过多轮磷酸化使其与中心型受体的相互作用失活。研究人员猜想相似的细胞器特异性振荡可以更普遍地调节细胞器生物发生的时间和运行。

据了解,澳门永利网站,细胞器生物发生的准确开始和运行对于细胞生理至关重要。从S期开始,中心粒的生物发生受到Plk4的调节,澳门永利网址,这时一个子细胞中心体从既有母细胞的一侧生长。

附:英文原文

Title: An Autonomous Oscillation Times and Executes Centriole Biogenesis

Author: Mustafa G. Aydogan, Thomas L. Steinacker, Mohammad Mofatteh, Zachary M. Wilmott, Felix Y. Zhou, Lisa Gartenmann, Alan Wainman, Saroj Saurya, Zsofia A. Novak, Siu-Shing Wong, Alain Goriely, Michael A. Boemo, Jordan W. Raff

Issue&Volume: 2020-06-11

Abstract: The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base of the growing centriole initiates and times centriole biogenesis to ensure that centrioles grow at the right time and to the right size. The Plk4 oscillation is normally entrained to the cell-cycle oscillator but can run autonomously of it—potentially explaining why centrioles can duplicate independently of cell-cycle progression. Mathematical modeling indicates that the Plk4 oscillation can be generated by a time-delayed negative feedback loop in which Plk4 inactivates the interaction with its centriolar receptor through multiple rounds of phosphorylation. We hypothesize that similar organelle-specific oscillations could regulate the timing and execution of organelle biogenesis more generally.

DOI: 10.1016/j.cell.2020.05.018

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30613-9

期刊信息

Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216

官方网址:https://www.cell.com/

投稿链接:https://www.editorialmanager.com/cell/default.aspx


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