科学家绘制出小鼠全澳门永利官网脑突触的终身变化图谱2020-06-15 16:03

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本期文章:《科学》:Online/在线发表

英国爱丁堡大学Seth G. N. Grant课题组绘制出小鼠全脑突触的终身变化图谱。这一研究成果于2020年6月11日在线发表在国际学术期刊《科学》上。

研究人员以单突触分辨率分析了从出生到老年整个小鼠大脑中的50亿个兴奋性突触的分子和形态学多样性。连续的变化会改变整个生命周期中所有大脑区域的突触组成。

 

突触多样性的扩大会导致大脑区域的分化,直到成年早期,并且组成的变化会导致老年时的去分化。大脑的时空突触结构随着年龄变化可能会影响智力、记忆力以及行为障碍易感性。

 

据悉,突触将神经元连接在一起,形成大脑的回路,澳门永利官网,澳门永利网站,其分子组成控制先天和学习的行为。

 

附:英文原文

Title: A brain-wide atlas of synapses across the mouse lifespan

Author: Mélissa Cizeron, Zhen Qiu, Babis Koniaris, Ragini Gokhale, Noboru H. Komiyama, Erik Fransén, Seth G. N. Grant

Issue&Volume: 2020/06/11

Abstract: Abstract Synapses connect neurons together to form the circuits of the brain and their molecular composition controls innate and learned behavior. We have analyzed the molecular and morphological diversity of five billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the lifespan. Expansion in synapse diversity produces differentiation of brain regions until early adulthood and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for lifespan transitions in intellectual ability, memory, and susceptibility to behavioral disorders.

DOI: 10.1126/science.aba3163

Source: https://science.sciencemag.org/content/early/2020/06/10/science.aba3163

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/

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